Bulgarian Society of Dermatology

Journal of Clinical & Experimental Dermatology Research

Anti-Aging Effects of Nicotinamide Riboside (NR) Supplementation


Author(s): Saad AlSogair

Sirtuins show promise in prolonging lifespan, as shown by previous animal and human studies. They play a role in cellular responses against oxidative stress and in cellular metabolism while also maintaining the length of telomeres. To make sirtuins work, cells need NAD+. The bioavailability of NAD+ inside the cells decreases in normal aging and may add to physiological aging by decreasing the action of sirtuins. The NAD+ metabolites nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), which are forms of vitamin B3, can increase NAD+ levels and improves different physiological capacities in animal studies. Among these two metabolites, nicotinamide riboside (NR) is more available in food and has better cell permeability, since it does not require any transformation to different intermediates. NR is also proven to be safe by studies, while NMN is yet to demonstrate safety in human consumption. This article aims to discuss the anti-aging effects of nicotinamide riboside (NR), as well as its other health benefits. Overall, previous studies have shown that NR can increase mitochondrial biogenesis and oxidative metabolism, as well as prevent metabolic diseases, neurodegenerative disorders and age-related physiological decline. It effects on mitochondrial metabolism suggests that it could have significant applications in the treatment of age related diseases.